Applications of Likelihood-based inference with non-mechanistic and mechanistic models in infectious disease modeling

Presented June 21, 2019.

In this talk, Dr. Daihai He presents his recent works on applications of likelihood-based inference with non-mechanistic and mechanistic models in infectious disease modeling. Examples include modeling of the transmission of influenza, measles, yellow-fever virus, Zika virus, and Lassa-fever virus. Combined non-mechanistic and mechanistic models, we gain new insight into the mechanisms under the transmission of infectious diseases. 

June 21, 2019

Improving Varicella Investigation Completeness in Pennsylvania

Routine childhood administration of varicella-containing vaccine has resulted in the number of varicella (chickenpox) cases in Pennsylvania falling from nearly 3,000 cases in 2007 to less than 400 cases in 2017. Prior to 2018, the completeness of varicella case investigation data documented in Pennsylvania's electronic disease surveillance system (PA-NEDSS) was not routinely monitored by Department of Health (DOH) staff. A pilot project was initiated in April 2018 to monitor and improve completeness of select varicella case investigation variables.

June 18, 2019

Towards Obesity Surveillance Using Multifaceted Online Social Relational Factors in Reddit

Overweight and obesity are recognized as one of the greatest modern public health problems1, yet worldwide prevalence of obesity has nearly doubled over the past 30 years2. As part of a strategy to control the obesity pandemic, the WHO recommends an obesity surveillance at the population level3. Empirical studies have shown the importance of social networks in obesity4 and new strategies focusing on social interactions and environments have been proposed5 to prevent the further increase in obesity prevalence.

June 18, 2019

Mapping PPS: A case study of story map journals for interactive health reporting

How are interactive story map journals situated within the genre of interactive, health science reporting? How can reporting information to public audiences be theorized through traditional and contemporary understandings of new media genres in technical, health and science communication (1-7). Although the polio vaccine has eradicated the disease in the United States, and 99% worldwide (8), PPS has emerged as a present-day condition that continues to affect many polio survivors years after the initial onset and recovery.

June 18, 2019

Use of ESSENCE APIs to Support Flexible Analysis and Reporting

The ESSENCE application supports users' interactive analysis of data by clicking through menus in a user interface (UI), and provides multiple types of user defined data visualization options, including various charts and graphs, tables of statistical alerts, table builder functionality, spatial mapping, and report generation. However, no UI supports all potential analysis and visualization requirements.

June 18, 2019

A machine-learning algorithm to identify hepatitis C in health insurance claims data

Hepatitis C virus (HCV) infection is a leading cause of liver disease-related morbidity and mortality in the United States. Monitoring the burden of chronic HCV infection requires robust methods to identify patients with infection. Insurance claims data are a potentially rich source of information about disease burden, but often lack the laboratory results necessary to define chronic HCV infection.

June 18, 2019

Measuring trends in hepatitis C testing with commercial laboratory data

Hepatitis C virus (HCV) infection is a leading cause of liver disease-related morbidity and mortality in the United States. Approximately 75% of people infected with chronic HCV were born between 1945 and 1965. Since 2012, the CDC has recommended one-time screening for chronic HCV infection for all persons in this birth cohort (baby boomers). The United States Preventive Services Task Force (USPSTF) subsequently made the same recommendation in June 2013.

June 18, 2019

Use of N-grams and Term Relationship Graphs in the Syndrome Definition Development Process

The use of syndromic surveillance systems has evolved over the last decade, and increasingly includes both infectious and non- infectious topic areas. Public health agencies at the national, state, and local levels often need to rapidly develop new syndromic categories, or improve upon existing categories, to enhance their public health surveillance efforts. Documenting this development process can help support increased understanding and user acceptance of syndromic surveillance.

June 18, 2019

A Novel Method for Rapid Mapping of the Spatial Intensity of Influenza Epidemics

Surveillance of influenza epidemics is a priority for risk assessment and pandemic preparedness. Mapping epidemics can be challenging because influenza infections are incompletely ascertained, ascertainment can vary spatially, and often a denominator is not available. Rapid, more refined geographic or spatial intelligence could facilitate better preparedness and response.

June 18, 2019

Mental health outcomes for individuals with chronic hepatitis C infection.

Hepatitis C virus (HCV) infection is a leading cause of liver disease-related morbidity and mortality in the United States and HCV incidence has been increasing. Mental illness may impact the likelihood of initial HCV infection, progress and adherence to treatment along the hepatitis C care cascade, and risk of subsequent reinfection for those cured of hepatitis C. The relationship between HCV infection and mental illness is not well understood and many studies have lacked sufficient sample size to adjust for important confounders.

June 18, 2019

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