In 2017, FL Department of Health (DOH) became one of thirty-two states plus Washington, D.C funded by the Center for Disease Control and Prevention (CDC) under the ESOOS program. One of the objectives of this funding was to increase the timeliness of reporting on non-fatal opioid overdoses through syndromic surveillance utilizing either the emergency department (ED) or Emergency Medical Services (EMS) data systems. Syndromic case validation is an essential requirement under ESOOS for non-fatal opioid-involved overdose (OIOD).