As the lead for coordinating domestic incident management across all Federal departments and agencies, Department of Homeland Security is responsible for identifying emergency response resources. The 2014 Ebola ā Zaire outbreak in West Africa that became a Public Health Emergency of International Concern highlighted the need to understand the current and potential availability of diagnostic assays for a number of viral hemorrhagic fevers that may require similar response actions. A concatenated list of publically reported potential viral hemorrhagic fever diagnostic assays was therefore compiled. Etiologic agents in the families of Arena-, Bunya-, Filo-, and Flaviviridae were included in the analysis. This list identifies assays in various stages of development that could be submitted, at some point, to the Food and Drug Administration (FDA) under an Emergency Use Authorization (EUA) should such a need arise.
Objective
Provide a succinct review of potential developmental and commercial viral hemorrhagic fever diagnostic assays published in peer-reviewed literature and open-source platforms.