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Infectious Disease

Improvement of the Q fever epizootic and epidemiological surveillance system remains an urgent veterinary service and healthcare problem in Ukraine. The grounds for this should be laid by the results of monitoring studies of persons with a professional infection risk (livestock farms, animal processing enterprises, veterinary specialists, etc.) and living in enzootic territories , as well as research of Q fever pathogen possible sources reservoirs.

Objective:

To investigate Q fever pathogen distribution among ixodic ticks, myomorphic rodents, febrile patients, residents of enzootic areas with Q fever and persons in contact with Q fever, specifically infected persons in the Southern and Western regions of Ukraine.

Submitted by elamb on

Natural foci of especially dangerous pathogens (EDP) (tularemia, leptospirosis, anthrax, tick-borne infections) are known in Lviv oblast for more than 50 years. An integral part of the epidemiological surveillance of these infections is the monitoring of environmental objects that can detect the circulation of pathogens in natural biotopes. Identification and studying of the activity of natural foci of EDP in the territory of Lviv oblast in previous years was conducted using classical laboratory and epidemiological methods.

Objective:

Study the advantages of using the PCR method for monitoring of natural foci within the EDP surveillance system.

Submitted by elamb on

Mortality rate of leptospirosis in Ukraine remains high year after year. The study of the peculiarities of lethal cases over a long period enables researchers to specify possible mechanisms of infection which cause the development of the severest cases of leptospirosis and to prevent disease emergence by applying adequate preventive measures.

Objective:

Study of the structure of lethal cases in patients diagnosed with leptospirosis in the Lviv Region.

Submitted by elamb on

Flaviviridae are one of the most widespread arboviruses in Ukraine. Mosquitoes are vectors of WNF in a majority of cases due to bites during swimming, fishing, work in suburban areas and outdoor recreation without use of individual protection from mosquitoes. A study of the species composition of bloodsucking mosquitoes is conducted in Ukraine. Existence of natural foci of WNF viruses has been well-proven all over the territory of Ukraine by testing IgG antibodies in different groups of population, including children. Also, infection of mosquitoes (RNA found in Culex pipiens (including Culex pipiens f. molestus, Culiseta annulata)) was registered. Infection of I. ricinus and D. reticulates was also determined, and it acts as a factor for circulation of virus in the wild too.

Objective:

To define the problems of epidemiological surveillance of West Nile fever (WNF) in Ukraine.

Submitted by elamb on

Guillain-Barre Syndrome (GBS) is a severe paralytic neuropathy associated with virus infections such as Zika virus and Chikungunya virus. There were also case reports of dengue fever preceding GBS. With the aim to understand the mechanisms of GBS and dengue outbreaks, this ecological study investigates the relationships between GBS, dengue, meteorological factors in Hong Kong and global climatic factors from January 2000 to June 2016.

Objective:

To study the trends of GBS and dengue in Hong Kong, the ecological associations between GBS, dengue, and local meteorological factors. To examine the non-stationary oscillating association among these factors.

Submitted by elamb on

Scarlet fever is a notifiable disease in Hong Kong for over 40 years. There was relatively low activity of scarlet fever until an outbreak in mid-2011 which resulted in two deaths and more than 1,500 cases. Scarlet fever incidence remained elevated since then with >10-fold increase comparing to that before the upsurge. Reemergence of scarlet fever was also reported in China in 2011 and the United Kingdom in 2014. We analyzed the patterns in scarlet fever incidence in Hong Kong using the notifiable disease surveillance data from 2005-2015.

Objective:

This study examined the epidemiology of scarlet fever in Hong Kong based on notifiable disease surveillance data, in a period where a 10-fold upsurge in scarlet fever incidence occurred. High risk groups and important factors associated with scarlet fever transmission were identified.

Submitted by elamb on

Different studies have shown that Streptococcal infections in adults are more common among older age, blacks, and underlying chronic medical conditions like diabetes, cardiovascular and kidney diseases. In specific, other studies have demonstrated that streptococcal pyogenes can cause severe illnesses and dramatic hospital outbreaks. Furthermore, community-acquired pneumonia studies had also suggested that cardiovascular disease, severe renal disease, chronic lung disease and diabetes were associated with increased odds of hospitalization.

Objective:

To study the factors associated with streptococcal infection that led to hospitalization in Houston, Texas for years 2015-2016

Submitted by elamb on

Each significant outbreak and epidemic raises questions that must be answered in order to better inform future preparedness and response efforts, such as:

  • What are the systems and resources needed to characterize an outbreak?
  • What systems and resources are needed to bring an outbreak to a close?

While we can anticipate these types of questions, the absence of dedicated mechanisms to record operational experiences and challenges can result in valuable, ephemeral data that are crucial for improving outbreak response not being consistently collected or analyzed. Participation in outbreaks by external experts can be instrumental in ensuring that this important operational information is documented, analyzed and shared with the broader public health community. There is a particular need for observers external to the response who can capture and analyze applied data about the operational response to outbreaks—eg, the systems and strategies involved in responding to the such events ”in order to improve our understanding of best practices for detecting and responding to these events. These can then be shared so that the entire public health community can access and incorporate lessons learned into their own preparedness and response plans. External observers can also help describe the important work performed by local responders during outbreaks and advocate for necessary preparedness and response program resources. The Outbreak Observatory is currently in a pilot phase and is looking for international and US partners who may be interested in collaborating with members of our team during their next outbreak response.

Objective:

The Outbreak Observatory (OO) aims to:

  • Strengthen outbreak/epidemic preparedness and response activities through real-time, one-the-ground observations and analyses ●Identify best practices based on operational experience that are broadly applicable across outbreak response agencies
  • Serve as an independent voice to advocate for policies that support preparedness and response activities based on expert assessment of the resources required to build and maintain necessary outbreak response capabilities Support local practitioners’ efforts to publish their experiences
  • Sharing the firsthand experience of responders is critical for building outbreak preparedness and response capacity, and OO will serve as a dedicated mechanism to collect, analyze and disseminate this information
Submitted by elamb on

The evolution of novel influenza viruses in humans is a bio- logical phenomenon that can not be stopped. All existing data suggest that vaccination against the morbidity and mortality of the novel influenza viruses is our best line of defence. Unfortunately, vaccination requires that the infectious agent to be quickly identified and a safe vaccine in large quantities is produced and administered. As was witnessed with the 2009 H1N1 influenza pandemic, these steps took a frustratingly long period during which the novel influenza virus continued its unstoppable and rapid global spreading. In addition to the different vaccination strategies ( e.g. random mass vaccination, age structured vaccination), isolation and quarantining of infected individuals is another effective method used by the public health agencies to control the spreading of infectious diseases. Isolation is effective against any infectious disease, however it can be very hard to detect infectious individuals in the population when: 1. Symptoms are ambiguous or easily misdiagnosed ( e.g. 2009 H1N1 influenza outbreak shared many symptoms with many other influenza like illnesses) 2. When the symptoms emerge after the individual become infectious.

Objective

The purpose of our work is to develop a system for automatic contact tracing with the goal of identifying individuals who are most likely infected, even if we do not have direct diagnostic information on their health status. Control of the spread of respiratory pathogens (e.g. novel influenza viruses) in the population using vaccination is a challenging problem that requires quick identification of the infectious agent followed by large-scale production and administration of a vaccine. This takes a significant amount of time. A complementary approach to control transmission is contact tracing and quarantining, which are currently applied to sexually transmitted diseases (STDs). For STDs, identifying the contacts that might have led to disease transmission is relatively easy; however, for respiratory pathogens, the contacts that can lead to transmission include a huge number of face-to-face daily social interactions that are impossible to trace manually.

 



 

Submitted by Magou on

Effective responses to epidemics of infectious diseases hinge not only on early outbreak detection, but also on an assessment of disease severity. In recent work, we combined previously developed ARI case-detection algorithms (CDA) [1] with text analyses of chest imaging reports to identify ARI patients whose providers thought had pneumonia. In this work, we asked if a surveillance system aimed at patients with pneumonia would outperform one that monitors the full severity spectrum of ARI.

Objective

To determine if influenza surveillance should target all patients with acute respiratory infections (ARI) or only track pneumonia cases.

 

Submitted by Magou on
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