H5N1 virus occurs mainly in birds. It is highly contagious and deadly among them. However, transmission in human is rare. The first and only confirmed case of human infection with avian influenza H5N1 virus in Nigeria was in 2006. Sporadic infection among poultry has been occurring in Nigeria with yearly estimated loss of millions of Dollars. Six Local Government Areas of Oyo State, Nigeria reported confirmed cases of H5N1 among birds. Affected birds were culled and human avian influenza surveillance was instituted. Samples were taken from human throat, assessment on awareness of poultry farmers on early recognition of A1 was done and sensitization among community members was conducted. due to increase awareness, more farmers now report cases of death in poultry early in Oyo state of Nigeria. All these activities were possible with prompt collaboration between Ministry of Health and Ministry of Agriculture.