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Evaluating Outbreak-Detection Methods Using Simulations: Volume Under the Time-ROC Surface

Description

There are many proposed methods of identifying outbreaks of disease in surveillance data. However, there is little agreement about appropriate ways to choose amongst them. One common basis for comparison is simulating outbreaks and adding the simu lated cases to real data streams (‘injected outbreaks’); competing statistical methods then attempt to detect the outbreak. The receiver operating characteristic (ROC) curve and the area beneath it are well-known approaches to evaluation. The ROC curve plots the sensitivity against 1 less the specificity for a range of decision thresholds. Unfortunately, defining ROC curves in this context is not straightforward. In the usual setting of screening, ROC curves are constructed based on individuals, not populations, and it is unclear how to extend the concept to surveillance. In addition, the sensitivity and specificity need to be supplemented by the timeliness: a method with perfect sensitivity and specificity that detects outbreaks too late is useless.

 

Objective

We developed metrics for evaluating tools used for outbreak detection, assuming simulated outbreaks.

Submitted by elamb on