California continues to face a serious public health crisis with the opioid epidemic having substantial health and economic impacts. The epidemic is dynamic and rapidly changing, involving both prescription opioids influenced by prescribing and dispensing patterns as well as illicit opioids influenced by the availability of heroin and recently, the increased availability of fentanyl. The complexity of the issue necessitates data-informed actions through multi-sector, strategic collaboration at both the state and local levels to address the problem comprehensively.