Abernethy Neil

Syndromic surveillance data such as the incidence of influenza-like illness (ILI) is broadly monitored to provide awareness of respiratory disease epidemiology. Diverse algorithms have been employed to find geospatial trends in surveillance data, however, these methods often do not point to a route of transmission. We seek to use correlations between regions in time series data to identify patterns that point to transmission trends and routes. Toward this aim, we employ network analysis to summarize the correlation structure between regions, whereas also providing an interpretation based on infectious disease transmission. 

Cross-correlation has been used to quantify associations between climate variables and disease transmission. The related method of autocorrelation has been widely used to identify patterns in time series surveillance data. This research seeks to improve interpretation of time series data and shed light on the spatial–temporal transmission of respiratory infections based on cross-correlation of ILI case rates.

Objective

Time series of ILI events are often used to depict case rates in different regions. We explore the suitability of network visualization to highlight geographic patterns in this data on the basis of cross-correlation of the time series data. 

Effective use of data for disease surveillance depends critically on the ability to trust and quantify the quality of source data. The Scalable Data Integration for Disease Surveillance project is developing tools to integrate and present surveillance data from multiple sources, with an initial focus on malaria. Consideration of data quality is particularly important when integrating data from diverse clinical, population-based, and other sources. Several global initiatives to reduce the burden of malaria (Presidents Malaria Initiative, Roll Back Malaria Initiative and The Global Fund to Fight AIDS, Tuberculosis and Malaria) have published lists of recommended indicators. Values for these indicators can be obtained from different data sources, with each source having different data quality properties as a consequence of the type of data collected and the method used to collect the data. Our goal is to develop a framework for organizing the data quality (DQ) properties of indicators used for disease surveillance in this setting.

There is growing recognition that an inability to access timely health indicators can hamper both the design and the effective implementation of infectious diseases control interventions. In malaria control, the global use of standard interventions has driven down the burden of disease in many regions. Further gains in high transmission areas and elimination in lower transmission settings, however, will require an enhanced understanding of malaria epidemiology, population characteristics, and efficacy of clinical and public health programs at the local level. Currently, there is a dearth of information available to fine-tune malaria control interventions at the local level. A key obstacle is the fragmentation of data into silos, as existing data cannot be brought together to estimate accurate and timely health metrics.

Objective

Driven by the need to bring malaria surveillance data from different sources together to support evidence-based decision making, we are conducting the “Scalable Data Integration for Disease Surveillance” (SDIDS) project. This project aims to foster the integration of existing surveillance data to support evidence-based decision-making in malaria control and demonstrate a model applicable to other diseases. Central to this initiative is collaboration between academia, governmental and NGO sectors.

Investigation of cases, clusters, and outbreaks of infectious disease is a complex process requiring substantial support from protocols, distributed and cooperative work, and information systems. We set out to identify public health information needs, the types of data required to meet these needs, and the potential alignment with visualizations of this data.

Objective

The goal of this work is to identify specific work practices in disease investigation that would be supported by data visualization, such as identifying exposure, contact, and spatiotemporal clustering.

Electronic data that could be used for global health surveillance are fragmented across diseases, organizations, and countries. This fragmentation frustrates efforts to analyze data and limits the amount of information available to guide disease control actions. In fields such as biology, semantic or knowledge-based methods are used extensively to integrate a wide range of electronically available data sources, thereby rapidly accelerating the pace of data analysis. Recognizing the potential of these semantic methods for global health surveillance, we have developed the Scalable Data Integration for Disease Surveillance (SDIDS) software platform. SDIDS is a knowledge-based system designed to enable the integration and analysis of data across multiple scales to support global health decision-making. A ‘proof of concept’ version of SDIDS is currently focused on data sources related to malaria surveillance in Uganda.

Objective

To develop a scalable software platform for integrating existing global health surveillance data and to implement the platform for malaria surveillance in Uganda.